A 9-year old boy from a village south of the town Barinas / Venezuela is suffering fever since 10 days, feels weak and has arthralgias. Above the upper parts of his nose a reddish, painful region of the skin had developed with a diameter of 2,5 cm. The fact, that the boy came from an endemic region of the Chagas disease was the reason to make a special examination of his blood which confirmed the presence of parasites of the protozoan species Trypanosoma cruzi. Therefore a so called chagoma was assumed to be present produced by the sting of a vector. Another consequence of a primary infection of this kind is the Romaña sign which we will describe in the next case.