Show simple item record

dc.rights.licensehttp://creativecommons.org/licenses/by-nc-sa/3.0/ve/
dc.contributor.authorMacías, Francisco A.es_VE
dc.contributor.authorMarín, Davides_VE
dc.contributor.authorOliveros Bastidas, Albertoes_VE
dc.contributor.authorMolinillo G., Josées_VE
dc.date2007-04-09es_VE
dc.date.accessioned2007-04-09T09:00:00Z
dc.date.available2007-04-09T09:00:00Z
dc.date.created2006-01-01es_VE
dc.date.issued2007-04-09T09:00:00Zes_VE
dc.identifier.otherT016300003777/0es_VE
dc.identifier.urihttp://www.saber.ula.ve/handle/123456789/16807
dc.description.abstractOptimization of Benzoxazinones as natural herbicide models by Lipophilicity Enhancement. (Macías, Francisco A.; Marín, David; Oliveros Bastidas, Alberto y Molinillo G., José Abstract Benzoxazinones are plant allelochemicals well-known for their phytotoxic activity and for taking part in the defense strategies of Gramineae, Ranunculaceae, and Scrophulariceae plants. These properties, in addition to the recently optimized methodologies for their large-scale isolation and synthesis, have made some derivatives of natural products, 2,4-dihydroxy-(2H)-1,4-benzoxazin-3-(4H)-one (DIBOA) and its 7-methoxy analogue (DIMBOA), successful templates in the search for natural herbicide models. These new chemicals should be part of integrated methodologies for weed control. In ongoing research about the structure-activity relationships of benzoxazinones and the structural requirements for their phytotoxicity enhancement and after characterization of the optimal structural features, a new generation of chemicals with enhanced lipophilicity was developed. They were tested on selected standard target species and weeds in the search for the optimal aqueous solubility-lipophilicity rate for phytotoxicity. This physical parameter is known to be crucial in modern drug and agrochemical design strategies. The new compounds obtained in this way had interesting phytotoxicity profiles, empowering the phytotoxic effect of the starting benzoxazinone template in some cases. Quantitative structure-activity relationships were obtained by bioactivity-molecular parameters correlations. Because optimal lipophilicity values for phytotoxicity vary with the tested plant, these new derivatives constitute a more selective way to take advantage of benzoxazinone phytotoxic capabilities.es_VE
dc.format.extent491194es_VE
dc.language.isoeses_VE
dc.publisherSABER ULAes_VE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGrupo de Química Ecológicaes_VE
dc.titleOptimization of Benzoxazinones as natural herbicide models by Lipophilicity enhancement.es_VE
dc.typeinfo:eu-repo/semantics/article
dc.description.emailfamacias@uca.eses_VE
dc.description.emailaloliver@ula.vees_VE
dc.description.tiponivelNivel monográficoes_VE
dc.subject.departamentoDepartamento de Químicaes_VE
dc.subject.escuelaEscuela de Ciencias.es_VE
dc.subject.facultadFacultad de Ciencias.es_VE
dc.subject.keywordsAllelochemicalses_VE
dc.subject.keywordsDIBOAes_VE
dc.subject.keywordsDIMBOAes_VE
dc.subject.keywordsD-DIBOAes_VE
dc.subject.keywordsLipophilicityes_VE
dc.subject.keywordsHerbicideses_VE
dc.subject.keywordsStructure Activity Relationships (SAR)es_VE
dc.subject.tipoArtículoses_VE


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record