A 61-years old female patient from the State Barinas / Venezuela presents a circular, coin-like ulceration on the left cheek. It was neither painful nor itching and had a diameter of 3 cm. clinically and histologically a Leishmaniasis was assumed. Several intracellular small granules were seen. Later, it could be confirmed that instead of a Leishmaniasis a histoplasmosis existed which could be proved by the Grocott method and by culture.