Fig.15-A1
Paracoccidioidomycosis

A 45-years old worker from the vicinity of the town Barinas / Venezuela complains for several months about toothache and ulceration at the right side of his tongue, which is growing continuously. Furthermore, some enlarged lymph nodes are palpable at the lower yaw border. The tongue is thickened and the ulcer is hardly seen.

Fig.15-A2
Paracoccidioidomycosis

A biopsy taken from the border of the ulcer of the tongue shows a cell-rich granulation tissue with giant cells containing roundish, optically empty elements. HE stain, low power magnification.

Fig.15-A3
Paracoccidioidomycosis

The round, optically empty elements turn out to be typical yeast cells of Paracoccidioides brasiliensis partly with multiple budding. GMS stain.