http://www.saber.ula.ve/handle/123456789/2277 Articulos, Pre-prints del Laboratorio de Fisiología de la Conducta Tue, 07 Apr 2026 08:20:51 GMT 2026-04-07T08:20:51Z http://www.saber.ula.ve/handle/123456789/39696 Mejorar la atención médica, ¿una utopía? Páez, Ximena Artículo próximamente ha ser publicado en la Revista Investigación, Revista del Consejo de Desarrollo Científico, Humanístico y Tecnológico - CDCHT - ULA. Wed, 01 Jan 2003 00:00:00 GMT http://www.saber.ula.ve/handle/123456789/39696 2003-01-01T00:00:00Z http://www.saber.ula.ve/handle/123456789/16076 IP3 receptors and associated Ca2+ signals localize to satellite cells and to components of the neuromuscular junction in skeletal muscle. Colasante, Cesare; Molgó, Jordi; Adams, Dany S.; Jaimovich, Enrique; Bohlen, MacKenzie; Williams, Aislinn; Powell, Jeanne A. IP3 receptors and associated Ca2+ signals localize to satellite cells and to components of the neuromuscular junction in skeletal muscle. (Powell, Jeanne A., Molgó, Jordi, Adams, Dany S., Colasante, Cesare, Williams, Aislinn, Bohlen, MacKenzie and Jaimovich, Enrique.) This paper was published on The Journal of Neuroscience, August 27, 2003This paper is dedicated to Jeanne A. Powell, to honor her memory. Sat, 15 Mar 2008 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16076 2008-03-15T09:00:00Z http://www.saber.ula.ve/handle/123456789/16089 Comités de ética Páez, Ximena Tue, 06 Feb 2007 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16089 2007-02-06T09:00:00Z http://www.saber.ula.ve/handle/123456789/16072 El error en medicina Páez, Ximena Tue, 06 Feb 2007 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16072 2007-02-06T09:00:00Z http://www.saber.ula.ve/handle/123456789/16078 Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased. Colasante, Cesare; Van der Kloot, William; Molgó, Jordi; Cameron, Roger Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased.(Van der Kloot William , Molgó Jordi , Cameron Roger and Colasante Cesare.) This papers was published on Journal of Physiology (2002), DOI: 10.1113 jphysiol.2001.014407 Fri, 01 Jul 2005 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16078 2005-07-01T09:00:00Z http://www.saber.ula.ve/handle/123456789/16088 IP³ receptors and Ca²+ signals in adult skeletal muscle satellite cells in situ. Colasante, Cesare; Molgó, Jordi; Adams, Dany S.; Jaimovich, Enrique IP³ receptors and Ca²+ signals in adult skeletal muscle satellite cells in situ.(Molgó, Jordi, Colasante, Cesare, Adams, Dany S. and Jaimovich, Enrique.) Abstract In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of receptor (IP3R) immunostaining was detected in satellite cells. These cells were identified by their peripheral position, their size, the shape of their nucleus, the paucity of the apparent cytoplasm, and the immunostaining with specific molecular markers such as a-actinin, the neural cell adhesion molecule (N-CAM) and desmin. High extracellular K+ (60 mM) induced long-lasting Ca²+; signals in satellite cells in situ. We suggest that electrical activity stimulates IP3-associated Ca²+; signals that could act in concert with signaling pathways triggered by growth factors and/or hormones. This paper is dedicated to the memory of Dr. Jeanne A. Powell. Fri, 01 Jul 2005 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16088 2005-07-01T09:00:00Z http://www.saber.ula.ve/handle/123456789/16095 Neuregulins: Primary or secondary signals for the control of synapse-specific gene expression. Colasante, Cesare Neuregulins: Primary or secondary signals for the control of synapse-specific gene expression.(Colasante, Cesare.) Abstract The selective transcription of acetylcholine receptor (AChR) subunit genes in synaptic myonuclei leads to the accumulation of AChR subunit mRNAs at the neuromuscular junction (NMJ). This mechanism contributes to the concentration of AChRs at the postsynaptic sarcolemma, and its physiological significance is underscored by the cases of human congenital myasthenias caused by mutation in a cis-regulatory element of the AChR£-subunit promoter, which is necessary for its synaptic expression. The signal(s) that drives synapse-specific expression is unknown but neuregulin-1 (Nrg-1), a group of growth-factor-like polypeptides encoded by the nrg-1 gene, has been a favorite candidate. Nrg-1 was originally thought as a nerve-derived factor, acting in parallel to pathways controlling AChR clustering at the synapse (i.e. agrin signaling). However, recent work suggests that Nrg-1 may actually be a muscle-derived signal that is concentrated at the NMJ, together with its receptors, by agrin and that acts as a secondary, downstream signal to enhance synapse-specific AChR transcription. Here, I review studies for and against Nrg-1 as a secondary signal driving synapse-specific expression at the NMJ. In addition, I briefly present new evidence that raise the possibility that Nrgs encoded by the ngr-1-related gene nrg-2 might have a role controlling AChR expression. This paper was published on Journal of Neurocytology 32, 665-675 (2003) Section of Neurobiology, Institute for Cell and Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA Fri, 01 Jul 2005 09:00:00 GMT http://www.saber.ula.ve/handle/123456789/16095 2005-07-01T09:00:00Z